Pentosan Polysulfate
Pentosan Polysulfate Sodium
A semi-synthetic polysulfated xylan with structural similarity to glycosaminoglycans. Used clinically for interstitial cystitis and osteoarthritis, with emerging applications in tissue repair.
Typical Cost
$200-400/month (oral prescription)
Status
Research
Peptide Profile
Pentosan Polysulfate
Mechanism of Action
Replenishes glycosaminoglycan layer on bladder epithelium, provides protective coating for damaged cartilage, reduces inflammatory cytokines, and promotes tissue repair through growth factor stimulation.
Common Dosages
oral
100mg
3x daily · 3-6 months
subcutaneous
2mg/kg
Weekly · 6-12 weeks
Benefits
Bladder pain relief
Cartilage protection
Reduced joint inflammation
Improved joint function
Tissue healing support
Side Effects
Nausea
Diarrhea
Hair loss (rare)
Retinal pigment changes (rare with long-term use)
Headache
Key Research
Pentosan polysulfate in osteoarthritis
Demonstrated significant improvement in joint pain and function compared to placebo
Elmiron for interstitial cystitis
FDA approval based on significant reduction in bladder pain and urinary frequency
Regulatory Status
FDA-approved (Elmiron) for interstitial cystitis. Available by prescription. Compounded versions available for osteoarthritis.
Contraindications
- ⚠Bleeding disorders
- ⚠Retinal disease history
- ⚠Pregnancy/breastfeeding
GLP-1 users with joint concerns from rapid weight changes may benefit from comprehensive tissue support alongside SeraVia's wellness formulations.
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