MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c
A mitochondrial-derived peptide that regulates metabolic function. Known as an exercise mimetic that improves insulin sensitivity, increases fat oxidation, and enhances physical performance.
Typical Cost
$80-150/vial (10mg)
Status
Research
Peptide Profile
MOTS-c
Mechanism of Action
Translocates to nucleus and regulates metabolic genes. Activates AMPK pathway, improving glucose uptake and fatty acid oxidation. Enhances mitochondrial function and biogenesis.
Common Dosages
subcutaneous
5-10mg
3x weekly · 4-8 weeks
intranasal
1-2mg
Daily · 4-8 weeks
Benefits
Improved insulin sensitivity
Enhanced fat oxidation
Better exercise performance
Metabolic flexibility
Mitochondrial health
Potential longevity benefits
Side Effects
Injection site reactions
Mild fatigue
Headache
Sleep changes
Key Research
MOTS-c as an exercise mimetic
Demonstrated enhanced glucose uptake and fatty acid metabolism similar to exercise effects
Regulatory Status
Research chemical only. Not FDA-approved. Under investigation for metabolic diseases.
Contraindications
- ⚠Pregnancy/breastfeeding
- ⚠Active infections
MOTS-c's metabolic benefits complement GLP-1 therapy. SeraVia Energy+ Boost provides additional metabolic cofactors for enhanced results.
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