MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c
A 16-amino-acid mitochondrial-derived peptide that acts as a metabolic regulator through AMPK activation. Improves insulin sensitivity, promotes fat oxidation, and enhances exercise capacity.
Typical Cost
$80-150/vial (10mg)
Status
Research
Peptide Profile
MOTS-c
Mechanism of Action
Activates AMPK pathway to improve glucose uptake, enhance fat oxidation, and boost cellular energy production. Mimics exercise at the cellular level. Regulates metabolic homeostasis.
Common Dosages
subcutaneous
200-1000mcg
Daily · 8-12 weeks
Benefits
Enhanced insulin sensitivity
Improved fat oxidation
Better exercise capacity
Metabolic regulation
Potential longevity
Side Effects
Limited human data
Unknown long-term effects
Injection site reactions
Key Research
MOTS-c and metabolic regulation
Improved metabolic function and exercise capacity in animal models
MOTS-c AMPK activation
Demonstrated AMPK pathway activation for metabolic benefits
Regulatory Status
Research chemical only. No human clinical trials completed. Not FDA-approved.
Contraindications
- ⚠Pregnancy/breastfeeding
- ⚠Active cancer
GLP-1 users seeking metabolic optimization may consider MOTS-c alongside SeraVia formulations.
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