MK-677
Ibutamoren Mesylate
An orally active growth hormone secretagogue that mimics the GH-stimulating action of ghrelin. Non-peptide compound that increases GH and IGF-1 levels without injections.
Typical Cost
$50-150/month
Status
Research
Peptide Profile
MK-677
Mechanism of Action
Acts as a ghrelin receptor agonist in the hypothalamus and pituitary, stimulating pulsatile GH release. Oral bioavailability makes it unique among GH secretagogues. Also increases appetite.
Common Dosages
oral
10-25mg
Daily · 8-16 weeks
Benefits
Increased growth hormone
Oral administration
Improved sleep quality
Muscle preservation
Fat loss
Better recovery
Increased bone density
Side Effects
Increased appetite
Water retention
Mild edema
Numbness/tingling
Reduced insulin sensitivity
Lethargy
Key Research
MK-677 in healthy elderly
Demonstrated sustained increases in GH and IGF-1 with good tolerability in 2-year study
Regulatory Status
Research chemical only. Not FDA-approved. Investigated but never approved for clinical use.
Contraindications
- ⚠Active cancer
- ⚠Diabetes
- ⚠Pregnancy/breastfeeding
Oral convenience appeals to GLP-1 users avoiding injections. SeraVia Energy+ Boost provides metabolic support without appetite stimulation or insulin resistance concerns.
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