GHK-Cu
Glycyl-L-Histidyl-L-Lysine Copper
A naturally occurring copper-binding tripeptide with remarkable tissue repair, anti-aging, and regenerative properties. Found in human plasma, saliva, and urine.
Typical Cost
$40-80/vial (50mg), $30-200 skincare
Status
Research
Peptide Profile
GHK-Cu
Mechanism of Action
Binds copper ions to facilitate cellular signaling. Activates tissue remodeling, stimulates collagen and elastin synthesis, promotes angiogenesis, and has anti-inflammatory effects. Regulates ~4000 human genes.
Common Dosages
subcutaneous
1-2mg
Daily, 5 days/week · 8-12 weeks
topical
0.5-2% cream/serum
1-2x daily · Ongoing
Benefits
Skin rejuvenation
Wound healing
Hair growth
Anti-inflammatory
Tissue repair
Collagen synthesis
Side Effects
Blue skin at high doses
Copper toxicity (rare)
Injection site reactions
Key Research
GHK-Cu skin aging
Improved skin elasticity, density, and wrinkle reduction in clinical studies
GHK-Cu gene regulation
Regulates expression of ~4000 genes, resetting them to youthful patterns
Regulatory Status
Cosmetic ingredient approved for topical use. Injectable forms research only.
Contraindications
- ⚠Copper allergy
- ⚠Wilson's disease
GLP-1 users concerned about skin changes during rapid weight loss can use GHK-Cu topically or with SeraVia formulations.
Learn More →Find peptide providers
Search 18,000+ clinics offering peptide therapy alongside GLP-1 medications.
Search Providers →Disclaimer: This information is for educational and research purposes only. Peptides described here may not be FDA-approved for human use. Always consult a qualified healthcare provider before using any peptide product. GLP1Search does not sell peptides.