Which GLP-1 medication has the fewest side effects?

Side effect profiles are generally similar across GLP-1 medications, with gastrointestinal symptoms being most common. Individual tolerance varies significantly - a medication that causes severe nausea for one patient may be well-tolerated by another. Some evidence suggests that tirzepatide may have slightly higher rates of gastrointestinal side effects than semaglutide, particularly at higher doses. Daily liraglutide may cause more frequent but less severe nausea compared to weekly formulations. Starting at low doses and titrating slowly reduces side effects for all medications. If one GLP-1 causes intolerable side effects, switching to another may help since individual pharmacokinetics vary. No single medication is universally best-tolerated.