What should I know about GLP-1 medication side effects before starting treatment?

Before starting GLP-1 medication, understand that GI side effects are very common—up to 80% of users experience some degree of nausea, vomiting, diarrhea, or constipation, especially during the first few weeks. These side effects are usually temporary and improve as your body adjusts. However, serious side effects, while rare, can occur and require immediate medical attention.

Discuss your complete medical history with your healthcare provider, especially if you have a history of pancreatitis, gallbladder disease, kidney problems, thyroid cancer, or diabetic retinopathy. Review all your current medications for potential interactions. Have a plan for managing side effects, including dietary strategies, hydration goals, and when to contact your provider. Understand the titration schedule and don't rush dose increases. Most importantly, know the warning signs that require immediate medical attention, such as severe abdominal pain, persistent vomiting, or signs of dehydration.