What is compounded semaglutide and is it safe?

Compounded semaglutide is a pharmacy-prepared version of the drug created during manufacturer shortages. 503A compounding pharmacies create patient-specific formulations, while 503B facilities produce larger batches. Quality varies significantly between compounding pharmacies. Reputable compounders use the same base ingredients (semaglutide sodium or semaglutide acetate from FDA-registered suppliers) as brand-name products. However, dosing accuracy, sterility, and stability may differ. The FDA has warned about some compounding pharmacies using salt forms improperly. If considering compounded semaglutide, verify the pharmacy's licensing, inspection records, and whether they use FDA-registered active pharmaceutical ingredients.