What drug interactions should I be aware of with GLP-1 medications?

GLP-1 medications can interact with several medication classes. Most notably, they can affect the absorption of oral medications due to delayed gastric emptying. This is particularly important for medications that require rapid absorption or have a narrow therapeutic index. Some oral medications may need to be taken at different times relative to your GLP-1 injection.

GLP-1 medications also interact with diabetes medications like insulin and sulfonylureas, increasing hypoglycemia risk and often requiring dose reductions of those medications. They may also interact with warfarin and other blood thinners, requiring closer INR monitoring. Additionally, GLP-1 medications can affect the absorption of oral contraceptives, potentially reducing effectiveness. Always inform all your healthcare providers that you're taking a GLP-1 medication, and review your complete medication list regularly for potential interactions.