What drug interactions should I avoid with GLP-1 medications?

GLP-1 medications have relatively few significant drug interactions compared to many medications, but some combinations require caution. Medications that slow gastric emptying (opioids, anticholinergics, some antidepressants) may compound GLP-1 effects and increase GI side effects or ileus risk. Oral medications may have delayed or reduced absorption due to slower gastric emptying - this particularly affects oral contraceptives (backup contraception recommended), antibiotics, and other time-sensitive medications. Take oral medications at least 1 hour before GLP-1 injection when possible. Alcohol increases nausea and dehydration risk. Insulin and sulfonylureas require dose adjustments to prevent hypoglycemia. Warfarin effects may be altered with significant weight loss - INR monitoring is important. Some antibiotics and medications requiring therapeutic drug monitoring may need dose adjustments. Always provide your complete medication list to all healthcare providers, including over-the-counter drugs and supplements. Your pharmacist can check for interactions when filling new prescriptions.