FDA approval for weight management GLP-1 medications specifies adults aged 18 and older. For adolescents, Wegovy (semaglutide 2.4mg) is approved for ages 12 and up with BMI at or above the 95th percentile for age and sex, or BMI at 85th percentile plus one weight-related comorbidity. The approval was based on the STEP TEENS trial showing 16% average weight loss in adolescents. Saxenda (liraglutide) is also approved for ages 12-17. For adults, there's no upper age limit, though providers may exercise additional caution in patients over 75 due to increased risk of side effects, falls from dizziness, and the need for adequate nutrition in older adults. Some providers prescribe off-label for younger adolescents in severe cases, but this is not standard practice and requires specialist oversight.
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