How do I deal with loose skin during rapid weight loss?

Loose skin is a common concern with significant weight loss, though GLP-1-induced gradual loss (1-2 pounds weekly) allows more skin adaptation than rapid loss. Factors affecting loose skin include: age (younger skin has more elasticity), amount of weight lost, speed of loss, genetics, smoking history, and sun damage. While no cream or supplement eliminates loose skin, certain strategies help: strength training to build muscle that fills some loose areas, staying hydrated for skin elasticity, consuming adequate protein and vitamin C for collagen synthesis, and losing weight at moderate pace (not exceeding 2 pounds weekly). Collagen supplements show mixed evidence but may help some individuals. Time improves loose skin for up to 2 years after weight loss as skin gradually contracts. For significant loose skin affecting quality of life, body contouring surgery is an option after weight has stabilized for 6-12 months. Many patients find loose skin concerns diminish compared to health improvements from weight loss.