Are there people who shouldn't take GLP-1 medications?

Several groups should avoid GLP-1 medications: pregnant or breastfeeding women; those with personal/family history of medullary thyroid carcinoma or MEN2; patients with prior pancreatitis; individuals with severe gastroparesis; patients with active eating disorders; those with known hypersensitivity to the drug or components; and patients with type 1 diabetes (not approved, though some specialists use off-label with caution). Relative contraindications requiring careful consideration include: severe gastrointestinal disease, history of gallbladder issues, severe renal impairment, diabetic retinopathy with recent treatment, history of suicidal ideation or depression (rare psychological side effects reported), and alcohol use disorder (increases pancreatitis risk). Age over 75 requires caution due to nutrition concerns and fall risk. Always provide your complete medical history to your prescriber, including over-the-counter medications and supplements that might interact.